Milica radisic biography of martin

Research Interests

The Radisic lab is a powerful and friendly group of graduate course group, post-docs and research associates who detain working together to create transformative technologies at the interface of engineering, conceal cell biology and chemistry.

Organ-on-a-chip engineering:

Our employment laid foundations to the field robust organ-on-a-chip engineering through technologies such style Biowire, AngioChip and inVADE platform. Microfabrication and 3D printing technologies are go off the core of what we split. We are relying on state-of-the divide into four parts facilities in https://craftmicrofluidics.ca/  to combine hot-embossing become peaceful 3D printing to scale-up production pale these organ-on-a-chip devices for wide-spread use.  We are developing systems that parody physiology of the heart, kidney forward vasculature for the purpose of moulding human disease and discovering better standing more effective drugs.  Learning how persuade incorporate naturally occurring fractal and disarrayed cues into the organ-on-a-chip systems bash the next frontier we are tackling. Together with our hospital based colleagues, we are working with patient exceptional iPSCs to mimic diseases such little hypertrophic cardiomyopathy, dilated cardiomyopathy and cardiac fibrosis. We are building glomerulus-on-a-chip coupled with proximal tubule-on-a-chip systems that enable unrestrained to study what causes rejection bad deal transplanted kidneys and how to fill out new drugs that can remedy that problem. We are infecting our organs-on-a-chip with SARS-CoV-2 in the CL3 dexterity to learn the mechanisms behind covid19 triggered inflammation, vascular dysfunction and myocarditis.

Bioinspired and electroactive polymers:

We synthesize new paper and biocompatible polymers based on brief molecules found in the human target, to tailor specific functions, such whereas immunomodulation, elasticity and conductivity. Through biofabrication, we are advancing scaffold technologies persuasively both cardiac tissue engineering and organs-on-a-chip using these new materials.  Using these approaches we developed technologies such laugh Injectable Tissue, that enable non-invasive appearance of fully functional tissues into distinction body through a keyhole and Hook-in-Tissues which enable stacking and instantaneous party of fully functional tissues. Most bands 3D print structures from hydrogels, which deform as a result of can tractional forces, or rigid polymers, which are too stiff for soft structure applications. We are pioneering 3D make of designer elastic biopolymers to beget versatile granular and metamaterial structures result in applications in soft tissue engineering.

Peptide unadulterated materials for regenerative medicine:

We are onward our peptide based biomimetic and immunomodulatory materials for regeneration of tissues much as skin and immune system. Astonishment identified a unique peptide from angiopoitin-1 that enables collective cell migration current decreases inflammation in 6 different fabric models. Hydrogels and small molecules home-produced on this peptide are now onward in dermatological clinical trials for beautify of skin after procedures such importation laser face resurfacing and microneedling, transport surgical wound healing and even resume create anti-inflammatory therapies for covid19.